Current advances in Zika vaccine development

Y Wang, L Ling, Z Zhang, A Marin-Lopez - Vaccines, 2022 - mdpi.com
Zika virus (ZIKV), an emerging arthropod-borne flavivirus, was first isolated in Uganda in
1947 from monkeys and first detected in humans in Nigeria in 1952; it has been associated …

Viral infections during pregnancy: the big challenge threatening maternal and fetal health

W Yu, X Hu, B Cao - Maternal-Fetal Medicine, 2022 - mednexus.org
Viral infections during pregnancy are associated with adverse pregnancy outcomes,
including maternal and fetal mortality, pregnancy loss, premature labor, and congenital …

Decision tree based ensemble machine learning model for the prediction of Zika virus T-cell epitopes as potential vaccine candidates

SNH Bukhari, J Webber, A Mehbodniya - Scientific Reports, 2022 - nature.com
Zika fever is an infectious disease caused by the Zika virus (ZIKV). The disease is claiming
millions of lives worldwide, primarily in developing countries. In addition to vector control …

Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples

M Karlikow, SJR da Silva, Y Guo, S Cicek… - Nature Biomedical …, 2022 - nature.com
In low-resource settings, resilience to infectious disease outbreaks can be hindered by
limited access to diagnostic tests. Here we report the results of double-blinded studies of the …

Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery

RZ Essa, Y Wu, K Batumalaie, M Sekar, C Poh - Pharmacological Reports, 2022 - Springer
The global pandemic of COVID-19 is a serious public health concern. Over 625 million
confirmed cases and more than 6 million deaths have been recorded worldwide. Although …

Apoptosis during ZIKA virus infection: too soon or too late?

J Turpin, D El Safadi, G Lebeau, M Krejbich… - International Journal of …, 2022 - mdpi.com
Cell death by apoptosis is a major cellular response in the control of tissue homeostasis and
as a defense mechanism in the case of cellular aggression such as an infection. Cell self …

Computational approaches in the discovery and development of therapeutic and prophylactic agents for viral diseases

A Gaurav, N Agrawal, M Al-Nema… - Current topics in …, 2022 - ingentaconnect.com
Over the last two decades, computational technologies have played a crucial role in antiviral
drug development. Whenever a virus spreads and becomes a threat to global health, it …

Effectiveness of Aedes-borne infectious disease control in Latin America and the Caribbean region: A scoping review

V Mulderij-Jansen, P Pundir, ME Grillet, T Lakiang… - Plos one, 2022 - journals.plos.org
Background Aedes aegypti and Aedes albopictus are primary vectors of emerging or re-
emerging arboviruses that threaten public health worldwide. Many efforts have been made …

NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review

DAF Nunes, FRS Santos… - Journal of Medical …, 2022 - Wiley Online Library
Zika virus (ZIKV) infections are associated with severe neurological complications and are a
global public health concern. There are no approved vaccines or antiviral drugs to inhibit …

Antiviral peptides as anti-influenza agents

M Agamennone, M Fantacuzzi, G Vivenzio… - International Journal of …, 2022 - mdpi.com
Influenza viruses represent a leading cause of high morbidity and mortality worldwide.
Approaches for fighting flu are seasonal vaccines and some antiviral drugs. The …