Polygenic scores: prediction versus explanation
R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …
the behavioural sciences. The ability to directly assess people's genetic propensities has …
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction
F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …
complex inheritance. In the past decade, successful identification of numerous susceptibility …
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …
health disparities. We propose PolyPred, a method that improves cross-population …
Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
Principal component analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated
E Elhaik - Scientific Reports, 2022 - nature.com
Abstract Principal Component Analysis (PCA) is a multivariate analysis that reduces the
complexity of datasets while preserving data covariance. The outcome can be visualized on …
complexity of datasets while preserving data covariance. The outcome can be visualized on …
Public human microbiome data are dominated by highly developed countries
The importance of sampling from globally representative populations has been well
established in human genomics. In human microbiome research, however, we lack a full …
established in human genomics. In human microbiome research, however, we lack a full …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
Increasing diversity in genomics requires investment in equitable partnerships and capacity building
Calls for diversity in genomics have motivated new global research collaborations across
institutions with highly imbalanced resources. We describe practical lessons we have …
institutions with highly imbalanced resources. We describe practical lessons we have …
[PDF][PDF] Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program
How race, ethnicity, and ancestry are used in genomic research has wide-ranging
implications for how research is translated into clinical care and incorporated into public …
implications for how research is translated into clinical care and incorporated into public …
Racialising genetic risk: assumptions, realities, and recommendations
JP Cerdeña, V Grubbs, AL Non - The Lancet, 2022 - thelancet.com
Scientists and clinicians wield the immense power of defining reality and producing facts. 1
Although no person can truly claim objectivity, scholars enjoy the authority of expertise and …
Although no person can truly claim objectivity, scholars enjoy the authority of expertise and …