Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

In recent work, Wang et al introduced the “Sum of Single Effects”(SuSiE) model, and showed
that it provides a simple and efficient approach to fine-mapping genetic variants from …

Sharing data across multiple institutions for genome-wide association studies (GWAS)
would enable discovery of novel genetic variants linked to health and disease. However …

Gout is a chronic disease of monosodium urate crystal deposition in the setting of
hyperuricemia that typically presents with recurrent flares of acute inflammatory arthritis that …

Identifying causal variants for complex traits is a major goal of human genetics research.
Despite the great success of genome-wide association studies (GWAS) in locus discovery …

Polygenic risk scores built from multi-ancestry genome-wide association studies (GWAS,
PRSmulti) have the potential to improve PRS accuracy and generalizability across …

We propose a novel Bayesian model for fine-mapping in order to identify putative causal
variants at GWAS loci. Relative to existing fine-mapping methods, the proposed model has …