Pancreatic cancer (PC) has one of the highest fatality rates and the currently available
therapeutic options are not sufficient to improve its overall poor prognosis. In addition to …

Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …

Combating fungal pathogens poses metabolic challenges for neutrophils, key innate cells in
anti-Candida albicans immunity, yet how host-pathogen interactions cause remodeling of …

Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for
tubular cells. However, the underlying mechanisms remain largely unknown. Here, we …

Malaria is a dangerous disease that contributes to millions of hospital visits and hundreds of
thousands of deaths, especially in children residing in sub-Saharan Africa. Although several …

Glucose is an important source of energy for the central nervous system. Its uptake at the
blood–brain barrier (BBB) is mostly mediated via glucose transporter 1 (GLUT1), a facilitated …

Background Human induced pluripotent stem cell (hiPSC)-derived brain endothelial-like
cells (iBECs) are a robust, scalable, and translatable model of the human blood–brain …

As a well-known glycolysis inhibitor for anticancer treatment, 2-Deoxy-D-glucose (2DG)
inhibits the growth and survival of cancer cells by interfering with the ATP produced by the …

Although great effort has been expended to understand cancer's origins, less attention has
been given to the primary cause of cancer deaths—cancer recurrences and their sequelae …

Colon cancer is a common malignant tumor in the digestive tract, with relatively high rates of
morbidity and mortality. It is the third most common type of tumor in the world. The effective …