The transport of mRNAs to distal subcellular compartments is an important component of
spatial gene expression control in neurons. However, the mechanisms that control mRNA …

Maternal RNA degradation is critical for embryogenesis and is tightly controlled by maternal
RNA-binding proteins. Fragile X mental-retardation protein (FMR1) binds target mRNAs to …

MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA
translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in …

Over the last one and a half decades, copy number variation and whole-genome
sequencing studies have illuminated the considerable genetic heterogeneity that underlies …

Learning and memory rely on long-lasting, synapse-specific modifications. Although
postsynaptic forms of plasticity typically require local protein synthesis, whether and how …

Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability,
resulting from a mutation in the FMR1 gene and subsequent loss of its protein product …

Abstract Background Fragile X syndrome (FXS), the most common genetic cause of autism
spectrum disorder and intellectual disability, is caused by the lack of fragile X mental …

How fragile X syndrome protein (FMRP) binds mRNAs and regulates mRNA metabolism
remains unclear. Our previous work using human neuronal cells focused on mRNAs …

Abstract Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary
intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select …

Fragile X Syndrome (FXS) is the most prevalent cause of inherited mental deficiency and is
the most common monogenetic cause of autism spectral disorder (ASD). Here, we …