SARS CoV-2 infections in animals, two years into the pandemic
S Frazzini, M Amadori, L Turin, F Riva - Archives of Virology, 2022 - Springer
In December 2019, several cases of pneumonia caused by a novel coronavirus, later
identified as SARS-CoV-2, were detected in the Chinese city of Wuhan. Due to its rapid …
identified as SARS-CoV-2, were detected in the Chinese city of Wuhan. Due to its rapid …
Benchmarking AlphaFold for protein complex modeling reveals accuracy determinants
High‐resolution experimental structural determination of protein–protein interactions has led
to valuable mechanistic insights, yet due to the massive number of interactions and …
to valuable mechanistic insights, yet due to the massive number of interactions and …
[HTML][HTML] Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice
Eliciting broadly neutralizing antibodies (bnAbs) is the core of HIV vaccine design. bnAbs
specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest …
specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest …
Glycans in HIV-1 vaccine design–engaging the shield
LP Deimel, X Xue, QJ Sattentau - Trends in Microbiology, 2022 - cell.com
Glycans are repeating carbohydrate structures added as post-translational modifications
(PTMs) to proteins, forming glycoproteins. Self-glycans found on human cells, and viral …
(PTMs) to proteins, forming glycoproteins. Self-glycans found on human cells, and viral …
Analysis of B cell receptor repertoires reveals key signatures of the systemic B cell response after SARS-CoV-2 infection
Y Zhang, Q Yan, K Luo, P He, R Hou, X Zhao… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A comprehensive study of the B cell response against SARS-CoV-2 could be
significant for understanding the immune response and developing therapeutical antibodies …
significant for understanding the immune response and developing therapeutical antibodies …
Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller
V Lorin, I Fernández, G Masse-Ranson… - Journal of Experimental …, 2022 - rupress.org
Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is
paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B …
paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B …
Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein
R Otsubo, T Minamitani, K Kobiyama, J Fujita, T Ito… - Scientific Reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have …
disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have …
Indirect Mechanisms of HIV-1 Evasion from Broadly Neutralizing Antibodies In Vivo
A Herschhorn - ACS Infectious Diseases, 2022 - ACS Publications
HIV-1 continues to be a major public health concern, with approximately 37.7 million people
living with HIV-1 worldwide at the end of 2021 (www. who. int). Broadly neutralizing …
living with HIV-1 worldwide at the end of 2021 (www. who. int). Broadly neutralizing …
Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env
The envelope glycoprotein (Env) is the sole target for neutralizing antibodies against HIV
and the most rapidly evolving, variable part of the virus. High-resolution structures of Env …
and the most rapidly evolving, variable part of the virus. High-resolution structures of Env …