Ferroptosis in glioma treatment: Current situation, prospects and drug applications
Y Zhou, C Fang, H Xu, L Yuan, Y Liu, X Wang… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is a regulatory form of iron-dependent cell death caused by the accumulation of
lipid-based reactive oxygen species (ROS) and differs from apoptosis, pyroptosis, and …
lipid-based reactive oxygen species (ROS) and differs from apoptosis, pyroptosis, and …
Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape
Non‐cutaneous melanomas most frequently involve the uveal tract and mucosal
membranes, including the conjunctiva. In contrast to cutaneous melanoma, they often …
membranes, including the conjunctiva. In contrast to cutaneous melanoma, they often …
Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence
L Yu, D Zhou, G Zhang, Z Ren, X Luo, P Liu… - Molecular …, 2022 - Wiley Online Library
Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations
in BRCA1‐associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a …
in BRCA1‐associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a …
Impact of long-term dietary habits on the human gut resistome in the Dutch population
PB Stege, J Hordijk, SA Shetty, M Visser, MC Viveen… - Scientific Reports, 2022 - nature.com
The human gut microbiome plays a central role in health and disease. Environmental
factors, such as lifestyle and diet, are known to shape the gut microbiome as well as the …
factors, such as lifestyle and diet, are known to shape the gut microbiome as well as the …
Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma
Abstract BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that is mutated in
cancer, including uveal melanoma. Loss-of-function BAP1 mutations are associated with …
cancer, including uveal melanoma. Loss-of-function BAP1 mutations are associated with …
BRCA-Mutated Pancreatic Cancer: From Discovery to Novel Treatment Paradigms
Simple Summary Approximately 10–20% of pancreatic cancer patients will have a mutation
in their DNA, passed on in families, that contributes to the development of their pancreatic …
in their DNA, passed on in families, that contributes to the development of their pancreatic …
Tumor suppressor BAP1 nuclear import is governed by transportin-1
Subcellular localization of the deubiquitinating enzyme BAP1 is deterministic for its tumor
suppressor activity. While the monoubiquitination of BAP1 by an atypical E2/E3-conjugated …
suppressor activity. While the monoubiquitination of BAP1 by an atypical E2/E3-conjugated …
Unusual suspects in hereditary melanoma: POT1, POLE, BAP1
Systematic literature searches on POT1/POLE/BAP1 found that limited skin phenotypic
characteristics have been documented in mutation carriers; 248 variants were annotated …
characteristics have been documented in mutation carriers; 248 variants were annotated …
[HTML][HTML] Diagnostic capacity of BAP1 and MTAP in cytology from effusions and biopsy in mesothelioma
LA Lynggård, V Panou, W Szejniuk, OD Røe… - Journal of the American …, 2022 - Elsevier
Introduction Serous effusion is often the first sign of mesothelioma. Diagnosis based on
cytologic material from the effusions remains controversial and complementary biopsy is …
cytologic material from the effusions remains controversial and complementary biopsy is …
[HTML][HTML] Clinical and molecular validation of BAP1, MTAP, P53, and Merlin immunohistochemistry in diagnosis of pleural mesothelioma
DB Chapel, JL Hornick, J Barlow, R Bueno, LM Sholl - Modern Pathology, 2022 - Elsevier
BAP1 and MTAP immunostains play an important role in diagnosis of mesothelioma, but
additional markers are needed to increase sensitivity. We analyzed 84 pleural …
additional markers are needed to increase sensitivity. We analyzed 84 pleural …