Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner
T Schumann, SC Ramon, N Schubert… - Journal of Experimental …, 2022 - rupress.org
Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …
[HTML][HTML] Directly injected lentiviral vector–based T cell vaccine protects mice against acute and chronic viral infection
T Tada, TD Norton, R Leibowitz, NR Landau - JCI insight, 2022 - ncbi.nlm.nih.gov
Lentiviral vector–based dendritic cell vaccines induce protective T cell responses against
viral infection and cancer in animal models. In this study, we tested whether preventative …
viral infection and cancer in animal models. In this study, we tested whether preventative …
[HTML][HTML] Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis
Background Type I interferon (IFN) inhibits virus infection through multiple processes.
Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the …
Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the …
[HTML][HTML] Transcriptomics and quantitative proteomics reveal changes after second stimulation of bone marrow-derived macrophages from lupus-prone MRL/lpr mice
K Chen, T Wu, D Wang, R Li, X Shen, T Zhao… - Frontiers in …, 2022 - frontiersin.org
Innate immune memory can cause the occurrence and exacerbation of autoimmune
diseases, and it is as well as being strongly associated with the pathogenesis of systemic …
diseases, and it is as well as being strongly associated with the pathogenesis of systemic …
[HTML][HTML] SAMHD1 promotes the antiretroviral adaptive immune response in mice exposed to lipopolysaccharide
BS Barrett, DH Nguyen, J Xu, K Guo… - The Journal of …, 2022 - journals.aai.org
SAMHD1 is a potent HIV-1 restriction factor that blocks reverse transcription in monocytes,
dendritic cells and resting CD4+ T cells by decreasing intracellular dNTP pools. However …
dendritic cells and resting CD4+ T cells by decreasing intracellular dNTP pools. However …
[图书][B] Host Gene Variants and Sting-Mediated Reactive Oxygen Species Affect Drosophila Melanogaster Survival During Coxiella burnetii Infection
RM Guzman - 2022 - search.proquest.com
The first line of defense against pathogens is referred to as innate immunity. At the molecular
level, innate immunity begins when pathogens are recognized by immune receptors which …
level, innate immunity begins when pathogens are recognized by immune receptors which …
cGAS/STING-dependent sensing of endogenous RNA
T Schumann, SC Ramon, N Schubert, MA Mayo… - Biorxiv, 2022 - biorxiv.org
Defects in nucleic acid metabolizing enzymes lead to spontaneous but selective activation of
either cGAS/STING or RIG-like receptor (RLR) signaling, causing a pathogenic type I …
either cGAS/STING or RIG-like receptor (RLR) signaling, causing a pathogenic type I …