Pathophysiology and mechanism of long COVID: a comprehensive review

D Castanares-Zapatero, P Chalon, L Kohn… - Annals of …, 2022 - Taylor & Francis
Background After almost 2 years of fighting against SARS-CoV-2 pandemic, the number of
patients enduring persistent symptoms long after acute infection is a matter of concern. This …

[HTML][HTML] Long COVID and its Management

HC Koc, J Xiao, W Liu, Y Li, G Chen - International journal of …, 2022 - ncbi.nlm.nih.gov
The pandemic of COVID-19 is the biggest public health crisis in 21 st Century. Besides the
acute symptoms after infection, patients and society are also being challenged by the long …

Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches

J Ahamed, J Laurence - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
SARS-CoV-2–infected individuals may suffer a multi–organ system disorder known as “long
COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). There are no standard …

Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis

JB Badenoch, ER Rengasamy, C Watson… - Brain …, 2022 - academic.oup.com
The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not
established. To help inform mental health service planning in the pandemic recovery phase …

SARS‐CoV‐2 and mitochondrial proteins in neural‐derived exosomes of COVID‐19

MJ Peluso, SG Deeks, M Mustapic… - Annals of …, 2022 - Wiley Online Library
Objective As SARS‐CoV‐2 is known to invade neural cell mitochondria, a plasma system for
quantifying central nervous system proteins in living humans was used to investigate …

Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis

T Yang, MZ Yan, X Li, EHY Lau - Infection, 2022 - Springer
Objective Although complications and clinical symptoms of COVID-19 have been elucidated,
the prevalence of long-term sequelae of COVID-19 is less clear in previously hospitalized …

Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model

C Käufer, CS Schreiber, AS Hartke, I Denden… - …, 2022 - thelancet.com
Background Neurological symptoms such as cognitive decline and depression contribute
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …

[HTML][HTML] Therapeutics for COVID-19 and post COVID-19 complications: An update

D Basu, VP Chavda, AA Mehta - Current Research in Pharmacology and …, 2022 - Elsevier
Since its inception in late December 2020 in China, novel coronavirus has affected the
global socio-economic aspect. Currently, the world is seeking safe and effective treatment …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients–indications for their potential involvement in the development of Long COVID?

S Haunhorst, W Bloch, F Javelle, K Krüger… - Frontiers in …, 2022 - frontiersin.org
Background Recovery from coronavirus disease 2019 (COVID-19) can be impaired by the
persistence of symptoms or new-onset health complications, commonly referred to as Long …