Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB)
signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell …

Dry eye disease (DED) is the most common ocular surface disease, characterized by
insufficient production and/or instability of the tear film. Tear substitutes are usually the first …

A meta-analytic approach was used to identify potential risk factors for dry eye syndrome.
PubMed, Embase, and the Cochrane library were systematically searched for studies …

Importance Dry eye is a common clinical manifestation, a leading cause of eye clinic visits,
and a significant societal and personal economic burden in the United States. Meibomian …

Purpose To evaluate the efficacy and safety of OC-01 (varenicline solution) nasal spray for
treatment of patients with dry eye disease. Design Randomized, multicenter, double …

Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …

The precorneal tear film is a complex mixture of proteins, lipids, metabolites, and electrolytes
with different structures and functionalities. Sustainable production of each tear component …

Nanoscale small extracellular vesicles (sEVs, exosomes) in tears allow us to investigate the
multisignatures of diseases. However, the translations of tear sEVs for biomarker discovery …

Dry eye disease (DED) is a highly prevalent and debilitating condition affecting several
hundred million people worldwide. Hyaluronic acid (HA) is a naturally occurring …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …