Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains
Eukaryotic chromosomes are folded into hierarchical domains, forming functional
compartments. Nuclear periphery and nucleolus are two nuclear landmarks contributing to …
compartments. Nuclear periphery and nucleolus are two nuclear landmarks contributing to …
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
J Kneppers, TM Severson, JC Siefert, P Schol… - Nature …, 2022 - nature.com
Androgen receptor (AR) drives prostate cancer (PCa) development and progression. AR
chromatin binding profiles are highly plastic and form recurrent programmatic changes that …
chromatin binding profiles are highly plastic and form recurrent programmatic changes that …
Extreme purifying selection against point mutations in the human genome
Large-scale genome sequencing has enabled the measurement of strong purifying
selection in protein-coding genes. Here we describe a new method, called ExtRaINSIGHT …
selection in protein-coding genes. Here we describe a new method, called ExtRaINSIGHT …
MaxHiC: A robust background correction model to identify biologically relevant chromatin interactions in Hi-C and capture Hi-C experiments
H Alinejad-Rokny, R Ghavami Modegh… - PLoS computational …, 2022 - journals.plos.org
Hi-C is a genome-wide chromosome conformation capture technology that detects
interactions between pairs of genomic regions and exploits higher order chromatin …
interactions between pairs of genomic regions and exploits higher order chromatin …
Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases
To determine the impact of genetic variants on the brain, we used genetically informed brain
atlases in genome-wide association studies of regional cortical surface area and thickness …
atlases in genome-wide association studies of regional cortical surface area and thickness …
Universal annotation of the human genome through integration of over a thousand epigenomic datasets
Background Genome-wide maps of chromatin marks such as histone modifications and
open chromatin sites provide valuable information for annotating the non-coding genome …
open chromatin sites provide valuable information for annotating the non-coding genome …
Genetic association between epigenetic aging-acceleration and the progression of mild cognitive impairment to Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and previous studies
have shown its association with accelerated aging. In this study, we hypothesized that single …
have shown its association with accelerated aging. In this study, we hypothesized that single …
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
TGFβ1 plays a regulatory role in the determination of renal cell fate and the progression of
renal fibrosis. Here we show an association between SMAD3 and the histone …
renal fibrosis. Here we show an association between SMAD3 and the histone …
The chromatin remodeling protein ATRX positively regulates IRF3-dependent type I interferon production and interferon-induced gene expression
AC Stilp, M Scherer, P König, A Fürstberger… - PLoS …, 2022 - journals.plos.org
The chromatin remodeling protein alpha thalassemia/mental retardation syndrome X-linked
(ATRX) is a component of promyelocytic leukemia nuclear bodies (PML-NBs) and thereby …
(ATRX) is a component of promyelocytic leukemia nuclear bodies (PML-NBs) and thereby …
SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease
We assess contributions to autoimmune disease of genes whose regulation is driven by
enhancer regions (enhancer-related) and genes that regulate other genes in trans …
enhancer regions (enhancer-related) and genes that regulate other genes in trans …