The robustness of cellular immunity determines the fate of SARS-CoV-2 infection

E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …

An immunologist's guide to immunosenescence and its treatment

C Caruso, ME Ligotti, G Accardi, A Aiello… - Expert review of …, 2022 - Taylor & Francis
Introduction Aging causes several changes in the immune system, although immune aging
is strongly influenced by individual immunological history, as well as genetic and …

[HTML][HTML] Engineered cell entry links receptor biology with single-cell genomics

B Yu, Q Shi, JA Belk, KE Yost, KR Parker, R Li, BB Liu… - Cell, 2022 - cell.com
Cells communicate with each other via receptor-ligand interactions. Here, we describe
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …

Evaluation of BCG vaccination and plasma amyloid: A prospective, pilot study with implications for Alzheimer's Disease

CT Dow, CL Greenblatt, ED Chan, JF Dow - Microorganisms, 2022 - mdpi.com
BCG vaccine has been used for 100 years to prevent tuberculosis. Not all countries,
including the United States, adopted the initial World Health Organization recommendation …

Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age

L Zuroff, A Rezk, K Shinoda, DA Espinoza, Y Elyahu… - …, 2022 - thelancet.com
Background Immunosenescence (ISC) describes age-related changes in immune-system
composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition …

Socioeconomic status and immune aging in older US adults in the health and retirement study

ET Klopack, B Thyagarajan, JD Faul… - … and social biology, 2022 - Taylor & Francis
Socioeconomic and demographic factors including educational attainment, race and
ethnicity, and childhood socioeconomic status (SES) are powerful predictors of inequalities …

Age-related adaptive immune changes in Parkinson's disease

A Kouli, CH Williams-Gray - Journal of Parkinson's Disease, 2022 - content.iospress.com
Ageing is a major risk factor for most neurodegenerative diseases, including Parkinson's
disease (PD). Progressive age-related dysregulation of the immune system is termed …

[HTML][HTML] T cell responses to SARS-CoV-2 in people with and without neurologic symptoms of long COVID

L Visvabharathy, BA Hanson, ZS Orban, PH Lim… - medRxiv, 2022 - ncbi.nlm.nih.gov
Many people experiencing long COVID syndrome, or post-acute sequelae of SARS-CoV-2
infection (PASC), suffer from debilitating neurologic symptoms (Neuro-PASC). However …

[HTML][HTML] Effect of panel reactive antibodies on T cell immunity reinstatement following renal transplantation

L Vagiotas, M Stangou, E Kasimatis… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Chronic kidney disease is associated with immunological disorders,
presented as phenotypic alterations of T lymphocytes. These changes are expected to be …

Identification of aging‐associated immunotypes and immune stability as indicators of post‐vaccination immune activation

A Cevirgel, SA Shetty, M Vos, NM Nanlohy… - Aging cell, 2022 - Wiley Online Library
Immunosenescence describes immune dysfunction observed in older individuals. To identify
individuals at‐risk for immune dysfunction, it is crucial to understand the diverse immune …