Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Increased insulin resistance and impaired insulin secretion are significant characteristics
manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these …

Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal
non-transcriptional functions in various biological processes critical for cellular homeostasis …

With the global increase of the elderly population, the improvement of the treatment for
various aging-related diseases and the extension of a healthy lifespan have become some …

Aneuploidy, the incorrect number of whole chromosomes, is a common feature of tumors
that contributes to their initiation and evolution. Preventing aneuploidy requires properly …

Normal spermatogenesis and sperm function are crucial for male fertility. The effects of
healthy testicular aging and testicular premature aging on spermatogenesis, sperm function …

One of the most striking findings in biogerontology in the 2010s was the demonstration that
elimination of senescent cells delays many late-life diseases and extends lifespan in mice …

The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint
(SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome …