Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents

A Najmi, SA Javed, M Al Bratty, HA Alhazmi - Molecules, 2022 - mdpi.com
Natural products represents an important source of new lead compounds in drug discovery
research. Several drugs currently used as therapeutic agents have been developed from …

Genistein: A review on its anti-inflammatory properties

YX Goh, J Jalil, KW Lam, K Husain… - Frontiers in …, 2022 - frontiersin.org
Nowadays, non-resolving inflammation is becoming a major trigger in various diseases as it
plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity …

Plant-derived natural products for drug discovery: current approaches and prospects

N Nasim, IS Sandeep, S Mohanty - The Nucleus, 2022 - Springer
Nature has abundant source of drugs that need to be identified/purified for use as essential
biologics, either individually or in combination in the modern medical field. These drugs are …

Antioxidants in brain tumors: current therapeutic significance and future prospects

X Qi, SK Jha, NK Jha, S Dewanjee, A Dey, R Deka… - Molecular Cancer, 2022 - Springer
Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor
microenvironment and inherent characteristics of brain tumor cells virtually render them …

The role of natural products and their multitargeted approach to treat solid cancer

N Muhammad, D Usmani, M Tarique, H Naz, M Ashraf… - Cells, 2022 - mdpi.com
Natural products play a critical role in the discovery and development of numerous drugs for
the treatment of various types of cancer. These phytochemicals have demonstrated anti …

Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement

V Aggarwal, HS Tuli, M Tania, S Srivastava… - Seminars in cancer …, 2022 - Elsevier
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of
epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid …

Natural products for cancer therapy: a review of their mechanism of actions and toxicity in the past decade

YO Ali Abdalla, B Subramaniam… - Journal of Tropical …, 2022 - Wiley Online Library
The ethnopharmacological information gathered over many centuries and the presence of
diverse metabolites have made the medicinal plants as the prime source of drugs. Despite …

Combination anticancer therapies using selected phytochemicals

WH Talib, D Awajan, RA Hamed, AO Azzam… - Molecules, 2022 - mdpi.com
Cancer is still one of the most widespread diseases globally, it is considered a vital health
challenge worldwide and one of the main barriers to long life expectancy. Due to the …

Combinatorial epigenetic mechanisms of sulforaphane, genistein and sodium butyrate in breast cancer inhibition

M Sharma, TO Tollefsbol - Experimental Cell Research, 2022 - Elsevier
Dietary phytochemicals are currently being studied with great interest due to their ability to
regulate the epigenome resulting in prevention of cancer. Some natural botanicals have …

Lotus (Nelumbo nucifera Gaertn.) and Its Bioactive Phytocompounds: A Tribute to Cancer Prevention and Intervention

A Bishayee, PA Patel, P Sharma, S Thoutireddy, N Das - Cancers, 2022 - mdpi.com
Simple Summary The plant Nelumbo nucifera (Gaertn.), commonly known as lotus, sacred
lotus, Indian lotus, water lily, or Chinese water lily, is an aquatic perennial crop belonging to …