Chronic low-grade elevations of blood-borne cytokines/chemokines in older age tend to
associate with frailty in humans. This persistent inflammation is often called “inflammageing” …

Introduction The incidence of rheumatoid arthritis (RA) and its complications are expected to
increase with age. Remarkably, RA patients were identified features of accelerated aging …

As an organism ages, its health-state is determined by a balance between the processes of
damage and repair. Measuring these processes requires longitudinal data. We extract …

In this review, we discuss in detail the most relevant proteolytic systems that together with
chaperones contribute to creating the proteostasis network that is kept in dynamic balance to …

Frailty is a state of accelerated aging that increases susceptibility to adverse health
outcomes. Due to its high societal and personal costs, there is growing interest in …

Frailty is a state of increased risk to health issues and can arise in older age and during
disease. Low circulating levels of testosterone, especially in older men, are thought to …

Exercise training prevents age-related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging …