[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

RA Fisher, JS Miners, S Love - Brain Pathology, 2022 - Wiley Online Library
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

J Dai, PJ Cimino, KH Gouin III, CA Grzelak, A Barrett… - Nature cancer, 2022 - nature.com
Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the
brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell …

Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Advances in designing of polymeric micelles for biomedical application in brain related diseases

J Kaur, M Gulati, B Kapoor, NK Jha, PK Gupta… - Chemico-Biological …, 2022 - Elsevier
In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …

Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native Aβ oligomers to rats

E Baerends, K Soud, J Folke, AK Pedersen… - Acta neuropathologica …, 2022 - Springer
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease
characterized by the accumulation of aggregated amyloid beta (Aβ) and …

The role of extracellular matrix alterations in mediating astrocyte damage and pericyte dysfunction in Alzheimer's disease: A comprehensive review

MM Anwar, E Özkan… - European Journal of …, 2022 - Wiley Online Library
The brain is a highly vascularized tissue protected by the blood–brain barrier (BBB), a
complex structure allowing only necessary substances to pass through into the brain while …

[HTML][HTML] Alzheimer's disease is an inherent, natural part of human brain aging: An integrated perspective

I Ferrer - Free Neuropathology, 2022 - ncbi.nlm.nih.gov
Alzheimer disease is one of the most challenging demons in our society due to its very high
prevalence and its clinical manifestations which cause deterioration of cognition …

The role of immunity in Alzheimer's disease

RM McManus - Advanced Biology, 2022 - Wiley Online Library
With the increase in the aging population, age‐related conditions such as dementia and
Alzheimer's disease will become ever more prevalent in society. As there is no cure for …

Histopathological Analysis of Cerebral Microvasculature Pathology with Alzheimer's Disease Neuropathological Changes: An Autopsy Study

Y Cao, MY Huang, CH Mao, X Wang, YY Xu, XJ Qian… - 2022 - researchsquare.com
Background: Cerebrovascular lesions are associated with cognitive impairment. However,
the implication of Alzheimer's disease (AD) neuropathological changes (ADNC) on cerebral …