Abstract Purpose of Review Acceleration of biological processes of aging is hypothesized to
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …

Background: Biological aging may be a robust biomarker of dementia or cognitive
performance. This systematic review synthesized the evidence for an association between …

Research on maternal-fetal epigenetic programming argues that adverse exposures to the
intrauterine environment can have long-term effects on adult morbidity and mortality …

Importance Accelerated aging makes adults more vulnerable to chronic diseases and death.
Whether childhood adversity is associated with accelerated aging processes, and to what …

Background ageing is an important risk factor for a variety of human pathologies. Biological
age (BA) may better capture ageing-related physiological changes compared with …

To define metrics of phenotypic aging, it is essential to identify biological and environmental
factors that influence the pace of aging. Previous attempts to develop aging metrics were …

Biological aging is a proposed mechanism through which social determinants drive health
disparities. We conducted proof-of-concept testing of 8 DNA-methylation (DNAm) and blood …

Abstract α-Klotho (klotho) is a protein involved in suppressing oxidative stress and
inflammation. In animal models, it is reported to underlie numerous aging phenotypes and …

Chronological age (CA) is determined by time of birth, whereas biological age (BA) is based
on changes on a cellular level and strongly correlates with morbidity, mortality, and …

Age-related alterations of the immune system represent a complex, multifactorial, and poorly
understood series of events that affect both the innate and adaptive compartments …