Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …

The dense neuropil of the central nervous system leaves only limited space for extracellular
substances free. The advent of immunohistochemistry, soon followed by advanced …

Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, and
are characterized by intraneuronal tau inclusion in the brain and the patient's cognitive …

The brain is a highly vascularized tissue protected by the blood–brain barrier (BBB), a
complex structure allowing only necessary substances to pass through into the brain while …

Background: Cerebrovascular lesions are associated with cognitive impairment. However,
the implication of Alzheimer's disease (AD) neuropathological changes (ADNC) on cerebral …