Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins
that frequently targets substrates for proteasomal degradation. However it can also result in …

Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the
maintenance of normal homeostasis in all eukaryotic cells. Several types of such self …

As an important post-translational modification, ubiquitination mediates∼ 80% of protein
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …

The signaling adaptor MAVS forms prion-like aggregates to activate the innate antiviral
immune response after viral infection. However, spontaneous aggregation of MAVS can …

Abstract Gasdermin-D (GSDMD), the executioner of pyroptotic cell death when it is cleaved
by inflammatory caspases, plays a crucial role in host defense and the response to danger …

African swine fever (ASF) is a devastating infectious disease caused by African swine fever
virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that …

Pyroptosis is a form of regulated cell death mediated by the gasdermin protein family. During
virus infection, cell pyroptosis restricts viral replication. The mechanisms of the tripartite motif …

Sensing of pathogen-associated molecular patterns including viral RNA by innate immunity
represents the first line of defense against viral infection. In addition to RIG-I-like receptors …

Influenza A viruses (IAVs) continuously challenge the poultry industry and human health.
Elucidation of the host factors that modulate the IAV lifecycle is vital for developing antiviral …

ABSTRACT REC8 meiotic recombination protein (REC8) is a member of structural
maintenance of chromosome (SMC) protein partners, which play an important role in …