Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

Exposure to chronic adverse conditions, and the resultant activation of the neurobiological
response cascade, has been associated with an increased risk of early onset of age-related …

As the global population becomes older, understanding the impact of aging on health and
disease becomes paramount. Recent advancements in multiomic technology have allowed …

As the whole world is epidemically aging, the burden of periodontitis and tooth loss is
becoming a major health concern. Growing meta-epidemiological data implicate chronic …

Abstract Purpose of Review Acceleration of biological processes of aging is hypothesized to
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …

Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …

To define metrics of phenotypic aging, it is essential to identify biological and environmental
factors that influence the pace of aging. Previous attempts to develop aging metrics were …