Shikonin and its derivatives, isolated from traditional medicinal plant species of the genus
Lithospermum, Alkanna, Arnebia, Anchusa, Onosma, and Echium belonging to the …

Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …

One of the leading global causes of death is cancer; even though several treatment methods
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …

MAS-related G protein-coupled receptors (GPCRs) of subfamily X, designated MRGPRX,
are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A …

NEMO/IKKβ complex is a central regulator of NF-κB signaling pathway, its dissociation has
been considered to be an attractive therapeutic target. Herein, using a combined strategy of …

Triple-negative breast cancer (TNBC) metastasis is the cause of nearly 90% of breast cancer
treatment failures as the side effects of clinical drugs and insufficient efficacy of single …

Arnebiae Radix (dried root of Arnebia euchroma (Royle) Johnst.) has been used in
traditional Chinese medicine (TCM) to treat macular eruptions, measles, sore throat …

Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several
cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5 …

DNA damage response (DDR) is a highly conserved genome surveillance mechanism that
preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules …

Shikonin (SK), a naphthoquinone compound from the purple gromwell, Lithospermum
erythrorhizon, possesses a considerable antiproliferative potential. By using a combination …