The ALDH2* 2 missense variant that commonly causes alcohol flushing reactions is the
single genetic polymorphism associated with the largest number of traits in humans. The …

Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge,,,–
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …

Abstract We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-
genome sequencing (WGS) individuals and 5,841 high-density genotyping individuals, and …

Despite substantial advances in disease genetics, studies to date have largely focused on
individuals of European descent. This limits further discoveries of novel functional genetic …

Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …

Objectives Autoimmune and allergic diseases are outcomes of the dysregulation of the
immune system. Our study aimed to elucidate differences or shared components in genetic …

Summary We reconstructed 19,084 prokaryotic and 31,395 viral genomes from 787
Japanese gut metagenomes as Japanese metagenome-assembled genomes (JMAG) and …

Intracranial germ cell tumors (IGCTs) are rare brain neoplasms that mainly occur in children
and adolescents with a particularly high incidence in East Asian populations. Here, we …

Background Some patients with inflammatory bowel disease (IBD) who were under
mesalamine treatment develop adverse reactions called “mesalamine allergy,” which …

The killer cell immunoglobulin-like receptor (KIR) recognizes human leukocyte antigen
(HLA) class I molecules and modulates the function of natural killer cells. Despite its role in …