Over the past decade, statistical methods have been developed to estimate single
nucleotide polymorphism (SNP) heritability, which measures the proportion of phenotypic …

Genome-wide association studies (GWASs) have successfully identified thousands of
genetic variants that are reliably associated with human traits. Although GWASs are …

Many traits are subject to assortative mating, with recent molecular genetic findings
confirming longstanding theoretical predictions that assortative mating induces long range …

Genetically informed, deep-phenotyped biobanks are an important research resource and it
is imperative that the most powerful, versatile, and efficient analysis approaches are used …

Heritability is a fundamental concept in genetic studies, measuring the genetic contribution
to complex traits and bringing insights about disease mechanisms. The advance of high …

Complex‐trait genetics has advanced dramatically through methods to estimate the
heritability tagged by SNPs, both genome‐wide and in genomic regions of interest such as …

Genome-wide association studies have revealed that the genetic architectures of complex
traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of …

Polygenic scores (PGS) have limited portability across different groupings of individuals (eg,
by genetic ancestries and/or social determinants of health), preventing their equitable use …

The 1997 film Gattaca has emerged as a canonical pop culture reference used to discuss
modern controversies in genetics and bioethics. It appeared in theaters a few years prior to …

A decade of genetic association studies in multiple organisms suggests that most complex
traits are polygenic; that is, they have a genetic architecture determined by numerous loci …