[HTML][HTML] The immune landscape of human pancreatic ductal carcinoma: key players, clinical implications, and challenges

M Muller, V Haghnejad, M Schaefer, G Gauchotte… - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …

The evolving role of immune cells in prostate cancer

C Wang, Y Zhang, WQ Gao - Cancer letters, 2022 - Elsevier
Prostate cancer is the most commonly diagnosed cancer and the second leading cause of
cancer-related death among men in western countries. Androgen deprivation therapy (ADT) …

[HTML][HTML] Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

M Qi, Y Xia, Y Wu, Z Zhang, X Wang, L Lu, C Dai… - Nature …, 2022 - nature.com
The formation of pre-metastatic niche is a key step in the metastatic burden. The pluripotent
factor Lin28B is frequently expressed in breast tumors and is particularly upregulated in the …

CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation

M Boieri, A Malishkevich, R Guennoun… - Journal of Experimental …, 2022 - rupress.org
Cancer immunology research is largely focused on the role of cytotoxic immune responses
against advanced cancers. Herein, we demonstrate that CD4+ T helper (Th2) cells directly …

Targeting glutamine metabolism to enhance immunoprevention of EGFR‐driven lung cancer

M Huang, D Xiong, J Pan, Q Zhang, S Sei… - Advanced …, 2022 - Wiley Online Library
Lung cancer is the leading cause of cancer death worldwide. Vaccination against EGFR can
be one of the venues to prevent lung cancer. Blocking glutamine metabolism has been …

Near‐infrared‐enpowered nanomotor‐mediated targeted chemotherapy and mitochondrial phototherapy to boost systematic antitumor immunity

X Zhang, Q He, J Sun, H Gong, Y Cao… - Advanced …, 2022 - Wiley Online Library
Phototherapy is an important strategy to inhibit tumor growth and activate antitumor
immunity. However, the effect of photothermal/photodynamic therapy (PTT/PDT) is restricted …

[HTML][HTML] Clinical predictive value of naïve and memory T cells in advanced NSCLC

G Zhang, A Liu, Y Yang, Y Xia, W Li, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Currently, there is no sensitive prognostic biomarker to screen out benefit patients from the
non-benefit population in advanced non-small cell lung cancer patients (aNSCLCs). The …

[HTML][HTML] Ferroptosis-related genes identify tumor immune microenvironment characterization for the prediction of prognosis in cervical cancer

X Yang, F Yin, Q Liu, Y Ma, H Zhang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Cervical cancer (CC) is a disease that affects female health; therefore, timely
prevention and diagnosis of CC are crucial to decrease its mortality. Ferroptosis, an iron …

[HTML][HTML] Rational development of molecularly imprinted nanoparticles for blocking PD-1/PD-L1 axis

Z Gu, S Xu, Z Guo, Z Liu - Chemical Science, 2022 - pubs.rsc.org
Blocking the PD-1/PD-L1 immune checkpoint has emerged as a promising strategy in
cancer immunotherapy, in which monoclonal antibodies are predominately used as …

How to overcome tumor resistance to anti-PD-1/PD-L1 therapy by immunotherapy modifying the tumor microenvironment in MSS CRC

L Chen, X Jiang, Y Li, Q Zhang, Q Li, X Zhang… - Clinical …, 2022 - Elsevier
Immune checkpoint inhibitors (ICIs), including anti-programmed cell death-1/anti-
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …