Recent advances and challenges in cancer immunotherapy

C Peterson, N Denlinger, Y Yang - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy helps a person's immune system to target tumor cells.
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …

Immune checkpoint inhibitors in cancer therapy—how to overcome drug resistance?

Y Lao, D Shen, W Zhang, R He, M Jiang - Cancers, 2022 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) are an important strategy in cancer
therapy. However, with the widespread clinical use of ICIs, people gradually found that ICIs …

Combination therapy with nivolumab (anti-PD-1 monoclonal antibody): A new era in tumor immunotherapy

BA Kiasari, A Abbasi, NG Darestani, N Adabi… - International …, 2022 - Elsevier
Immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1 or CD279)
have noticeably improved the treatment landscape of advanced cancer patients. Nivolumab …

Nano-drug delivery systems for T cell-based immunotherapy

R Li, Z Chen, J Li, Z Dai, Y Yu - Nano Today, 2022 - Elsevier
T cell-based immunotherapy, which tackles T cell dysfunction and exhaustion, offers broad
promising for treating cancer. Various T cell-based immunotherapies, such as immune …

The interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis

F Fakharian, B Asgari, A Nabavi-Rad… - Frontiers in cellular …, 2022 - frontiersin.org
The human gut microbiota are critical for preserving the health status because they are
required for digestion and nutrient acquisition, the development of the immune system, and …

New therapeutics for HCC: Does tumor immune microenvironment matter?

A Khanam, S Kottilil - International Journal of Molecular Sciences, 2022 - mdpi.com
The incidence of liver cancer is continuously rising where hepatocellular carcinoma (HCC)
remains the most common form of liver cancer accounting for approximately 80–90% of the …

Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review

F Eskandari-Malayeri, M Rezaei - Frontiers in Immunology, 2022 - frontiersin.org
The tumor microenvironment (TME) is a significant contributor to cancer progression
containing complex connections between cellular and chemical components and provides a …

Injectable hydrogel-based combination cancer immunotherapy for overcoming localized therapeutic efficacy

J Kim, Y Choi, DH Kim, HY Yoon, K Kim - Pharmaceutics, 2022 - mdpi.com
Various immunotherapeutic agents that can elicit antitumor immune responses have
recently been developed with the potential for improved efficacy in treating cancer. However …

Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy

L Yu, M Sun, Q Zhang, Q Zhou, Y Wang - Frontiers in immunology, 2022 - frontiersin.org
With the goal of harnessing the host's immune system to provide long-lasting remission and
cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy …

Biomimetic nanoparticles for tumor immunotherapy

H Yu, M Wu, S Chen, M Song, Y Yue - Frontiers in bioengineering …, 2022 - frontiersin.org
Currently, tumor treatment research still focuses on the cancer cells themselves, but the fact
that the immune system plays an important role in inhibiting tumor development cannot be …