Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Esophageal cancer (EC) is one of the most incident and lethal tumors worldwide. Although
surgical resection is an important approach in EC treatment, late diagnosis, metastasis and …

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin
polymerization inhibitors targeting the colchicine binding site. Among these compounds …

Purpose: Sabizabulin, an oral cytoskeleton disruptor, was tested in a phase Ib/II clinical
study in men with metastatic castration-resistant prostate cancer (mCRPC). Patients and …

Simple Summary The sabizabulin agent represses tumor cell growth, cell migration, and
colony formation, and induces cell death in HER2+ breast cancer models. Sabizabulin is …

Although the role of microtubule dynamics in cancer progression is well-established, the
roles of tubulin isotypes, their cargos and their specific function in the induction and …

The median overall survival of patients with metastatic breast cancer is only 2–3 years, and
for patients with untreated liver metastasis, it is as short as 4–8 months. Improving the …

Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer. Unlike
other subtypes of breast cancer, TNBC lacks hormone and growth factor receptor targets …

The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting
at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation …

Esophageal cancer (EC) is one of the most incident and lethal tumors worldwide. Although
surgical resection is an important approach in EC treatment, late diagnosis, metastasis and …