Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin
polymerization inhibitors targeting the colchicine binding site. Among these compounds …

A series of novel acridane-based tubulin polymerization inhibitors were designed,
synthesized, and bioevaluated as anticancer agents. The most potent compound NT-6 …

Simple Summary The sabizabulin agent represses tumor cell growth, cell migration, and
colony formation, and induces cell death in HER2+ breast cancer models. Sabizabulin is …

A novel series of diphenylamine derivatives were designed and synthesized, and their
biological activities were evaluated. The anti-proliferative activities of the derivatives were …

The construction of a virtual library (VL) consisting of novel molecules based on structure–
activity relationships is crucial for lead optimization in rational drug design. In this study, we …

Ligands binding to the colchicine domain of the tubulin protein act as tubulin polymerization
inhibitors and arrest the cell cycle in G2/M phase. A series of 4-Phenyl-1, 2, 3-triazole …

The colchicine binding site of tubulin is a promising target for discovering novel antitumor
agents which exert the antiangiogenic effect and are not susceptible to multidrug resistance …

A further investigation aiming to generate new potential antitumor agents led us to
synthesize a new series of twenty-two compounds characterized by the presence of the 7 …

Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer. Unlike
other subtypes of breast cancer, TNBC lacks hormone and growth factor receptor targets …