Nephron overload as a therapeutic target to maximize kidney lifespan

VA Luyckx, AD Rule, KR Tuttle, P Delanaye… - Nature Reviews …, 2022 - nature.com
Kidney lifespan is a patient-oriented outcome that provides much needed context for
understanding chronic kidney disease (CKD). Nephron endowment, age-associated decline …

Nutritional and non-nutritional strategies in bodybuilding: impact on kidney function

V Tidmas, J Brazier, J Hawkins, SC Forbes… - International journal of …, 2022 - mdpi.com
Bodybuilders routinely engage in many dietary and other practices purported to be harmful
to kidney health. The development of acute kidney injury, focal segmental glomerular …

Prognostic significance of urinary biomarkers in patients hospitalized with COVID-19

S Menez, DG Moledina, H Thiessen-Philbrook… - American Journal of …, 2022 - Elsevier
Rationale & Objective Acute kidney injury (AKI) is common in patients with coronavirus
disease 2019 (COVID-19) and associated with poor outcomes. Urinary biomarkers have …

[HTML][HTML] Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies

Z Yi, F Salem, MC Menon, K Keung, C Xi, S Hultin… - Kidney international, 2022 - Elsevier
Interstitial fibrosis, tubular atrophy, and inflammation are major contributors to kidney
allograft failure. Here we sought an objective, quantitative pathological assessment of these …

A disposable printed amperometric biosensor for clinical evaluation of creatinine in renal function detection

Y Dong, X Luo, Y Liu, C Yan, H Li, J Lv, L Yang, Y Cui - Talanta, 2022 - Elsevier
In clinical practice, sera creatinine level is regarded as a crucial biomarker for the diagnosis,
staging and monitoring of kidney disease. An amperometric biosensor is rapid, accurate …

Performance of creatinine‐based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment

P Delanaye, J Björk, M Courbebaisse… - British journal of …, 2022 - Wiley Online Library
Aim The Cockcroft‐Gault (CG) creatinine‐based equation is still used to estimate glomerular
filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous …

A Fluorescent Cage for Supramolecular Sensing of 3‐Nitrotyrosine in Human Blood Serum

LA Pérez‐Márquez, MD Perretti… - Angewandte Chemie …, 2022 - Wiley Online Library
Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen
species (RNS), and as a consequence it is accumulated in inflammation‐associated …

Glomerular function and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model

J Chang, GM Pais, K Valdez, S Marianski… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Clinical studies have reported additive nephrotoxicity associated with the combination of
vancomycin (VAN) and piperacillin-tazobactam (TZP). This study assessed differences in …

Uremia-Induced Gut Barrier Defect in 5/6 Nephrectomized Mice Is Worsened by Candida Administration through a Synergy of Uremic Toxin, Lipopolysaccharide, and (1➔3)-β-D …

S Tungsanga, W Panpetch… - International Journal of …, 2022 - mdpi.com
A chronic kidney disease (CKD) causes uremic toxin accumulation and gut dysbiosis, which
further induces gut leakage and worsening CKD. Lipopolysaccharide (LPS) of Gram …

Serum creatinine to cystatin C ratio and clinical outcomes in adults with non-dialysis chronic kidney disease

YY Hyun, KB Lee, H Kim, Y Kim, W Chung… - Frontiers in …, 2022 - frontiersin.org
Background Studies have suggested that the serum creatinine/cystatin C (Cr/CysC) ratio is a
surrogate marker for muscle wasting is associated with adverse outcomes in several …