BioRED: a rich biomedical relation extraction dataset

L Luo, PT Lai, CH Wei, CN Arighi… - Briefings in …, 2022 - academic.oup.com
Automated relation extraction (RE) from biomedical literature is critical for many downstream
text mining applications in both research and real-world settings. However, most existing …

Recent advances in predicting protein–protein interactions with the aid of artificial intelligence algorithms

S Li, S Wu, L Wang, F Li, H Jiang, F Bai - Current Opinion in Structural …, 2022 - Elsevier
Protein–protein interactions (PPIs) are essential in the regulation of biological functions and
cell events, therefore understanding PPIs have become a key issue to understanding the …

[HTML][HTML] Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease

J Xu, C Mao, Y Hou, Y Luo, JL Binder, Y Zhou… - Cell reports, 2022 - cell.com
Translating human genetic findings (genome-wide association studies [GWAS]) to
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …

[HTML][HTML] Identifying crosstalk genetic biomarkers linking a neurodegenerative disease, Parkinson's disease, and periodontitis using integrated bioinformatics analyses

S Hu, S Li, W Ning, X Huang, X Liu, Y Deng… - Frontiers in Aging …, 2022 - frontiersin.org
Objective To identify the genetic linkage mechanisms underlying Parkinson's disease (PD)
and periodontitis, and explore the role of immunology in the crosstalk between both these …

[HTML][HTML] Comprehensive network medicine-based drug repositioning via integration of therapeutic efficacy and side effects

P Paci, G Fiscon, F Conte, RS Wang… - NPJ systems biology …, 2022 - nature.com
Despite advances in modern medicine that led to improvements in cardiovascular outcomes,
cardiovascular disease (CVD) remains the leading cause of mortality and morbidity globally …

[HTML][HTML] Exploring protein-protein interactions at the proteome level

H Elhabashy, F Merino, V Alva, O Kohlbacher… - Structure, 2022 - cell.com
Proteins are central to all of the processes of life. For their activity, they almost invariably
need to interact with other macromolecules, be they nucleic acids, membranes, glycans, or …

[HTML][HTML] Repurposing drugs via network analysis: opportunities for psychiatric disorders

TTT Truong, B Panizzutti, JH Kim, K Walder - Pharmaceutics, 2022 - mdpi.com
Despite advances in pharmacology and neuroscience, the path to new medications for
psychiatric disorders largely remains stagnated. Drug repurposing offers a more efficient …

[HTML][HTML] ADH-PPI: An attention-based deep hybrid model for protein-protein interaction prediction

MN Asim, MA Ibrahim, MI Malik, A Dengel, S Ahmed - Iscience, 2022 - cell.com
Protein-protein interaction (PPI) prediction is essential to understand the functions of
proteins in various biological processes and their roles in the development, progression …

[HTML][HTML] Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease

C Gupta, J Xu, T Jin, S Khullar, X Liu… - PLoS Computational …, 2022 - journals.plos.org
Dysregulation of gene expression in Alzheimer's disease (AD) remains elusive, especially at
the cell type level. Gene regulatory network, a key molecular mechanism linking …

[HTML][HTML] Repurposing histaminergic drugs in multiple sclerosis

S Amadio, F Conte, G Esposito, G Fiscon… - International Journal of …, 2022 - mdpi.com
Multiple sclerosis is an autoimmune disease with a strong neuroinflammatory component
that contributes to severe demyelination, neurodegeneration and lesions formation in white …