Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics
S Vasishta, K Ganesh, S Umakanth, MB Joshi - Metabolomics, 2022 - Springer
Abstract Type 2 diabetes (T2D) associated health disparities among different ethnicities
have long been known. Ethnic variations also exist in T2D related comorbidities including …
have long been known. Ethnic variations also exist in T2D related comorbidities including …
Untargeted lipidomic analysis of plasma from obese women submitted to combined physical exercise
This study aimed to determine the changes of lipidome in obese women undergoing
combined physical exercise training. Fourteen adult women with obesity (mean BMI and …
combined physical exercise training. Fourteen adult women with obesity (mean BMI and …
Bezafibrate reduces elevated hepatic fumarate in insulin-deficient mice
A Franko, M Irmler, C Prehn, SS Heinzmann… - Biomedicines, 2022 - mdpi.com
Glucotoxic metabolites and pathways play a crucial role in diabetic complications, and new
treatment options which improve glucotoxicity are highly warranted. In this study, we …
treatment options which improve glucotoxicity are highly warranted. In this study, we …
Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles
Z Chen, S Han, P Zheng, J Zhang, S Zhou… - Particle and Fibre …, 2022 - Springer
Background The application of titanium dioxide nanoparticles (TiO2 NPs) as food additives
poses a risk of oral exposure that may lead to adverse health effects. Even though the …
poses a risk of oral exposure that may lead to adverse health effects. Even though the …
Plasma lipidomic subclasses and risk of hypertension in middle-aged and elderly Chinese
Z Niu, Q Wu, Y Luo, D Wang, H Zheng, Y Wu, X Yang… - Phenomics, 2022 - Springer
While disrupted lipid metabolism is a well-established risk factor for hypertension in animal
models, the links between various lipidomic signatures and hypertension in human studies …
models, the links between various lipidomic signatures and hypertension in human studies …
The treatment with the SGLT2 inhibitor empagliflozin modifies the hepatic metabolome of male Zucker diabetic fatty rats towards a protective profile
A Aragón-Herrera, M Otero-Santiago… - Frontiers in …, 2022 - frontiersin.org
The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients
with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose …
with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose …
[HTML][HTML] Circulating metabolites as a concept beyond tumor biology determining disease recurrence after resection of colorectal liver metastasis
JP Jonas, H Hackl, D Pereyra, J Santol, G Ortmayr… - HPB, 2022 - Elsevier
Background Micro-metastatic growth is considered the main source of early cancer
recurrence. Nutritional and microenvironmental components are increasingly recognized to …
recurrence. Nutritional and microenvironmental components are increasingly recognized to …
Loss of Focad, Operating in the SKI mRNA Surveillance Pathway, is Responsible for a Syndromic form of Pediatric Liver Cirrhosis
RM Traspas - 2022 - search.proquest.com
The human liver is endowed with intrinsic capability to regenerate upon injury. However,
when damage and inflammation persist, the organ may lose its regenerative potential …
when damage and inflammation persist, the organ may lose its regenerative potential …
Mitobullet: antioxidant targeting of mitochondria to prevent nonalcoholic fatty liver disease-induced oxidative stress
RFS Amorim - 2022 - estudogeral.uc.pt
Non-alcoholic fatty liver disease (NAFLD) is a public health concern affecting 24% of the
population worldwide. Non-alcoholic steatohepatitis (NASH), one of the deleterious stages …
population worldwide. Non-alcoholic steatohepatitis (NASH), one of the deleterious stages …