Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Best practice standards for circular RNA research

AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …

CircOGDH is a penumbra biomarker and therapeutic target in acute ischemic stroke

Y Liu, Y Li, J Zang, T Zhang, Y Li, Z Tan, D Ma… - Circulation …, 2022 - Am Heart Assoc
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality
worldwide. Prediction of penumbra existence after AIS is crucial for making decision on …

Exosomal RNAs: novel potential biomarkers for diseases—a review

J Wang, BL Yue, YZ Huang, XY Lan, WJ Liu… - International Journal of …, 2022 - mdpi.com
Exosomes are a subset of nano-sized extracellular vesicles originating from endosomes.
Exosomes mediate cell-to-cell communication with their cargos, which includes mRNAs …

Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

H Khanbabaei, S Ebrahimi… - Journal of Experimental …, 2022 - Springer
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic
development during which epithelial cells acquire mesenchymal characteristics, and the …

[HTML][HTML] Regulation of myogenic gene expression

C Vicente-García, JD Hernández-Camacho… - Experimental Cell …, 2022 - Elsevier
Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

[HTML][HTML] Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs

D Tsitsipatis, K Mazan-Mamczarz, Y Si… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Circular RNAs are abundant, covalently closed transcripts that arise in cells through back-
splicing and display distinct expression patterns across cells and developmental stages …

Enhanced myogenesis through lncFAM-mediated recruitment of HNRNPL to the MYBPC2 promoter

MW Chang, JH Yang, D Tsitsipatis, X Yang… - Nucleic Acids …, 2022 - academic.oup.com
The mammalian transcriptome comprises a vast family of long noncoding (lnc) RNAs
implicated in physiologic processes such as myogenesis, through which muscle forms …

ebv-circRPMS1 promotes the progression of EBV-associated gastric carcinoma via Sam68-dependent activation of METTL3

J Zhang, Y Du, L Gong, Y Shao, L Pan, Z Feng, Y Pan… - Cancer Letters, 2022 - Elsevier
Epstein–Barr virus (EBV) is a tumor virus that is associated with a variety of neoplasms,
including EBV-associated gastric carcinoma (EBVaGC). Recently, EBV was reported to …