The life of SARS-CoV-2 inside cells: Replication–transcription complex assembly and function
Z Lou, Z Rao - Annual Review of Biochemistry, 2022 - annualreviews.org
The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in
increasingly disruptive impacts, and it has become the most devastating challenge to global …
increasingly disruptive impacts, and it has become the most devastating challenge to global …
[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …
that outcomes are markedly heterogeneous between patients. This requires identifying the …
Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor Paxlovid
JT Lee, Q Yang, A Gribenko, BS Perrin Jr, Y Zhu… - Mbio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to represent a
global health emergency as a highly transmissible, airborne virus. An important coronaviral …
global health emergency as a highly transmissible, airborne virus. An important coronaviral …
AI-aided design of novel targeted covalent inhibitors against SARS-CoV-2
The drug repurposing of known approved drugs (eg, lopinavir/ritonavir) has failed to treat
SARS-CoV-2-infected patients. Therefore, it is important to generate new chemical entities …
SARS-CoV-2-infected patients. Therefore, it is important to generate new chemical entities …
Structural basis of the main proteases of coronavirus bound to drug candidate PF-07321332
J Li, C Lin, X Zhou, F Zhong, P Zeng, Y Yang… - Journal of …, 2022 - Am Soc Microbiol
The high mutation rate of COVID-19 and the prevalence of multiple variants strongly support
the need for pharmacological options to complement vaccine strategies. One region that …
the need for pharmacological options to complement vaccine strategies. One region that …
Benchmarking the ability of novel compounds to inhibit SARS-CoV-2 main protease using steered molecular dynamics simulations
Abstract Background The SARS-CoV-2 main protease (M pro) is an attractive target in the
COVID-19 drug development process. It catalyzes the polyprotein's translation from viral …
COVID-19 drug development process. It catalyzes the polyprotein's translation from viral …
[HTML][HTML] Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E
Since December 2019, the deadly novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the current COVID-19 pandemic. To date, vaccines are available …
(SARS-CoV-2) has caused the current COVID-19 pandemic. To date, vaccines are available …
Exploration of novel lichen compounds as inhibitors of SARS-CoV-2 Mpro: ligand-based design, molecular dynamics, and ADMET analyses
Abstract In the year 2019–2020, the whole world witnessed the spread of a disease called
COVID-19 caused by SARS-CoV-2. A number of effective drugs and vaccine has been …
COVID-19 caused by SARS-CoV-2. A number of effective drugs and vaccine has been …
Review on development of potential inhibitors of SARS-CoV-2 main protease (MPro)
SG Katre, AJ Asnani, K Pratyush, NG Sakharkar… - Future Journal of …, 2022 - Springer
Background The etiological agent for the coronavirus illness outbreak in 2019–2020 is a
novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
In-silico screening of plant-derived antivirals against main protease, 3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2
Abstract Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition
all over the world. The virus is highly infectious and spreads by human to human local …
all over the world. The virus is highly infectious and spreads by human to human local …