Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Tuberculosis (TB) is caused by infection with the bacterium Mycobacterium tuberculosis
(Mtb), which primarily infects the lungs but can also cause extrapulmonary disease. Both the …

Globally, autosomal recessive IFNAR1 deficiency is a rare inborn error of immunity
underlying susceptibility to live attenuated vaccine and wild-type viruses. We report seven …

Both host genetics and the gut microbiome have important effects on human health, yet how
host genetics regulates gut bacteria and further determines disease susceptibility remains …

Simple Summary This research found that a higher immune escape score was significantly
correlated with a shorter survival time. Meanwhile, through the validation of the external …

Natural resistance to infection is an overlooked outcome after hepatitis C virus (HCV)
exposure. Between 1977 and 1979, 1,200 Rhesus D-negative Irish women were exposed to …

Mycobacterium tuberculosis has developed diverse mechanisms to survive inside
phagocytic cells, such as macrophages. Phagocytosis is a key process in eliminating …

Abstract “吕贝克灾难”、 双胞胎研究及收养研究等流行病学观察性研究结果都充分表明，
宿主基因是决定机体对结核分枝杆菌是否易感和感染后是否发病的重要因素 …

Previous studies demonstrated that transforming growth factor (TGT) β1 plays an
immunosuppressive role in clinical tuberculosis. However, the contribution of TGF-β1 gene …

Mycobacterium tuberculosis (Mtb) infection induces persistent influx of neutrophils that
associates with poor bacterial control and clinical outcome from tuberculosis (TB). Although …