[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Recent applications of immunomodulatory biomaterials for disease immunotherapy

H Dai, Q Fan, C Wang - Exploration, 2022 - Wiley Online Library
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …

[HTML][HTML] Inhalable dry powder mRNA vaccines based on extracellular vesicles

KD Popowski, A Moatti, G Scull, D Silkstone, H Lutz… - Matter, 2022 - cell.com
Respiratory diseases are a global burden, with millions of deaths attributed to pulmonary
illnesses and dysfunctions. Therapeutics have been developed, but they present major …

[HTML][HTML] Intestinal fibrosis in inflammatory bowel disease and the prospects of mesenchymal stem cell therapy

Y Wang, B Huang, T Jin, DKW Ocansey… - Frontiers in …, 2022 - frontiersin.org
Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the
course of the development of fibrosis, certain parts of the intestine become narrowed …

SARS-CoV-2 infection and lung regeneration

F Zhao, Q Ma, Q Yue, H Chen - Clinical Microbiology Reviews, 2022 - Am Soc Microbiol
The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)-induced immunopathology whereby the virus enters the host cells by binding to …

[HTML][HTML] Scalable generation of nanovesicles from human-induced pluripotent stem cells for cardiac repair

J Lozano, A Rai, JG Lees, H Fang, B Claridge… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to
repair injured cardiac tissues and regulate pathological fibrosis. However, scalable …

[HTML][HTML] The role of the immune system in the pathogenesis of NAFLD and potential therapeutic impacts of mesenchymal stem cell-derived extracellular vesicles

Z Moayedfard, F Sani, A Alizadeh… - Stem cell research & …, 2022 - Springer
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by intra-hepatocyte
triglyceride accumulation and concomitant involvement of the immune system with …

[HTML][HTML] Stem cell-based therapy for pulmonary fibrosis

W Cheng, Y Zeng, D Wang - Stem Cell Research & Therapy, 2022 - Springer
Pulmonary fibrosis (PF) is a chronic and relentlessly progressive interstitial lung disease in
which the accumulation of fibroblasts and extracellular matrix (ECM) induces the destruction …

[HTML][HTML] Therapeutic role of mesenchymal stem cell-derived exosomes in respiratory disease

MJ Zargar, S Kaviani, M Vasei… - Stem Cell Research & …, 2022 - Springer
Exosomes are extracellular vesicles found in various tissues, blood circulation, and tissue
fluids, secreted into the extracellular environment by fusing a multivesicular body with a …

[HTML][HTML] Molecular insight into the therapeutic effects of stem cell-derived exosomes in respiratory diseases and the potential for pulmonary delivery

MH Azhdari, N Goodarzi, M Doroudian… - International Journal of …, 2022 - mdpi.com
Respiratory diseases are the cause of millions of deaths annually around the world. Despite
the recent growth of our understanding of underlying mechanisms contributing to the …