Multiple sclerosis and obesity: The role of adipokines

J Correale, M Marrodan - Frontiers in immunology, 2022 - frontiersin.org
Multiple Sclerosis (MS), a chronic inflammatory disease of the central nervous system that
leads to demyelination and neurodegeneration has been associated with various …

The underlying sex differences in neuroendocrine adaptations relevant to myalgic encephalomyelitis chronic fatigue syndrome

N Thomas, C Gurvich, K Huang, PR Gooley… - Frontiers in …, 2022 - Elsevier
Abstract Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a
complex multisystem disease characterised by severe and disabling new-onset symptoms of …

Age-period-cohort analysis of the incidence of multiple sclerosis over twenty years in Lorraine, France

B Gbaguidi, F Guillemin, M Soudant, M Debouverie… - Scientific Reports, 2022 - nature.com
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. An
increase in MS incidence over time is reported in several regions of the world. We aimed to …

Shift of multiple sclerosis onset towards older age

L Prosperini, M Lucchini, S Ruggieri… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective To explore whether age at onset increased over time despite a shortened interval
from the initial clinical demyelinating event to the diagnosis of multiple sclerosis (MS), as …

Sex differences in neurodegeneration: the role of the immune system in humans

C Lopez-Lee, L Kodama, L Gan - Biological psychiatry, 2022 - Elsevier
Growing evidence supports significant involvement of immune dysfunction in the etiology of
neurodegenerative diseases, several of which also display prominent sex differences across …

Updated perspectives on the challenges of managing multiple sclerosis during pregnancy

R Villaverde-González - Degenerative Neurological and …, 2022 - Taylor & Francis
Multiple sclerosis (MS) is a chronic immune-mediated, inflammatory, and degenerative
disease that is up to three times more frequent in young women. MS does not alter fertility …

[HTML][HTML] Multiple sclerosis by phenotype in Germany

J Engelhard, DM Oleske, S Schmitting, KE Wells… - Multiple sclerosis and …, 2022 - Elsevier
Background: A diagnosis of multiple sclerosis (MS) can be categorized based on its disease
course into the following phenotypes: relapsing-remitting MS (RRMS), primary progressive …

Epstein–Barr virus infection, B‐cell dysfunction and other risk factors converge in gut‐associated lymphoid tissue to drive the immunopathogenesis of multiple …

J Leffler, S Trend, PH Hart… - Clinical & Translational …, 2022 - Wiley Online Library
Multiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B‐cell dysfunction,
gut dysbiosis, and environmental and genetic risk factors, including female sex. A disease …

Increasing incidence and prevalence of multiple sclerosis in the Greater Hobart cohort of Tasmania, Australia

S Simpson-Yap, R Atvars, L Blizzard… - Journal of Neurology …, 2022 - jnnp.bmj.com
Background The Greater Hobart region (42.5° S) of Tasmania has consistently had the
highest recorded prevalence and incidence rates of multiple sclerosis (MS) in Australia. We …

Sex-specific environmental impacts on initiation and progression of multiple sclerosis

J Leffler, S Trend, S Gorman, PH Hart - Frontiers in Neurology, 2022 - frontiersin.org
The immunological mechanisms that contribute to multiple sclerosis (MS) differ between
males and females. Females are 2–3 times more likely to develop MS compared to males …