Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …

Stroke is the second leading cause of death and the third leading cause of disability
worldwide and its burden is increasing rapidly in low-income and middle-income countries …

Background Whether chlorthalidone is superior to hydrochlorothiazide for preventing major
adverse cardiovascular events in patients with hypertension is unclear. Methods In a …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

There is strong evidence that sex chromosomes and sex hormones influence blood
pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities …

High systolic blood pressure (SBP) is a major risk factor for ischemic heart disease (IHD), the
leading cause of death worldwide. Using data from published observational studies and …

Background Resistant hypertension is associated with increased cardiovascular risk. The
endothelin pathway has been implicated in the pathogenesis of hypertension, but it is …

Abstract Coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a real challenge for health …

As the leading cause of death worldwide, cardiovascular diseases (CVDs) present major
challenges for health systems. In this study, we analyzed the effects of better population …

Cardiovascular disease (CVD) is the leading cause of death in the Americas and raised
blood pressure accounts for over 50% of CVD. In the Americas over a quarter of adult …