A mitochondrial niche protects oocyte RNPs

M Almonacid, MH Verlhac - Developmental Cell, 2022 - cell.com
Preserving maternal RNA transmitted by the oocyte to its progeny is an essential aspect of
oogenesis, yet not much is known about how this is achieved in mammalian species. In a …

A meiotic midbody structure in mouse oocytes acts as a barrier for nascent translation to ensure developmental competence

GI Jung, D Londoño-Vásquez, S Park, AR Skop… - bioRxiv, 2022 - biorxiv.org
Successful embryo development is dependent upon maternally deposited components.
During egg formation, developmental competence is acquired through regulated translation …

Multi-Step Cellular Control of Molecular Condensation by Microtubules in Early Oogenesis

R Deis, S Kar, A Ahmad, Y Bogoch, A Dominitz… - bioRxiv, 2022 - biorxiv.org
Molecular condensates provide new paradigms in biology, but their cellular regulation is
unclear. Condensates undergo phase separation, decreasing their solubility and …