Catechins are key functional components in tea and have many health benefits, including
relieving diabetes. Glucose is necessary for maintaining life. However, when the glucose in …

Collagen is the central structural component of extracellular connective tissue, which
provides elastic qualities to tissues. For skeletal muscle, extracellular connective tissue …

The last few years important changes have occurred in the field of diabetes treatment. The
priority in the therapy of patients with diabetes is not glycemic control per se rather an overall …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors involved
in the regulation of almost all known physiological processes. Dysfunctions of GPCR …

Abstract Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed
as therapeutic agents for type 2 diabetes (T2D). GLP-1R is not only expressed in pancreatic …

Aims Emerging evidence suggests the existence of a crosstalk between dipeptidyl peptidase
4 (DPP4) and the renin-angiotensin system (RAS). Therefore, combined inhibition of DPP4 …

Abstract Dipeptidyl-peptidase-4 (DPP-4) is an enzyme having various properties and
physiological roles in lipid accumulation, resistance to anticancer agents, and immune …

The in silico prediction of T cell epitopes within any peptide or biologic drug candidate
serves as an important first step for assessing immunogenicity. T cell epitopes bind human …

Obesity is a major public health issue with an increasing prevalence worldwide. Excess
body fat is associated with various comorbidities, as well as increased overall mortality risk …

Introduction The prevalence of both obesity and osteoarthritis (OA) is increasing worldwide
(twindemic), and the association between the two chronic diseases is also well established …