[HTML][HTML] Advances in PSMA theranostics

TM Jeitner, JW Babich, JM Kelly - Translational Oncology, 2022 - Elsevier
The validation of prostate specific membrane antigen (PSMA) as a molecular target in
metastatic castration-resistant prostate cancer has stimulated the development of multiple …

The history of prostate-specific membrane antigen as a theranostic target in prostate cancer: the cornerstone role of the prostate cancer foundation

AK Miyahira, HR Soule - Journal of Nuclear Medicine, 2022 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a credentialed imaging and therapy
(theranostic) target for the detection and treatment of prostate cancer. PSMA-targeted PET …

[HTML][HTML] Prostate-specific membrane antigen–targeted theranostics: Past, present, and future approaches

NM Hawkey, AO Sartor, MJ Morris… - Clinical advances in …, 2022 - ncbi.nlm.nih.gov
Although prostate cancer is the type of cancer most commonly survived by men in the United
States, it remains the second most common cause of death from cancer, largely owing to …

[HTML][HTML] [99mTc]Tc-PSMA-T4—Novel SPECT Tracer for Metastatic PCa: From Bench to Clinic

M Maurin, M Wyczółkowska, A Sawicka, AE Sikora… - Molecules, 2022 - mdpi.com
Despite significant advances in nuclear medicine for diagnosing and treating prostate
cancer (PCa), research into new ligands with increasingly better biological properties is still …

[HTML][HTML] Expression of prostate specific membrane antigen (PSMA) in breast cancer

C Unger, P Bronsert, K Michalski… - Geburtshilfe und …, 2022 - thieme-connect.com
Hintergrund Das prostataspezifische Membranantigen (PSMA) ist für
Mammakarzinompatientinnen ein vielversprechendes Protein. Es wurde bisher nicht nur …

Role of 68Ga and 18F PSMA PET/CT and PET/MRI in biochemical recurrence of prostate cancer: a systematic review of prospective studies

W Mazrani, GJR Cook, J Bomanji - Nuclear medicine …, 2022 - journals.lww.com
Objective To systematically review the prospective literature on the role of 68 Ga and 18 F
PSMA PET/CT and PET/MRI as a tool for functional imaging in prostate cancer biochemical …

The importance of linkers in the structure of PSMA ligands

AA Uspenskaya, EA Nimenko… - Current Medicinal …, 2022 - ingentaconnect.com
Cancer is one of the leading social problems of the modern world. Today prostate cancer is
the second leading cause of cancer deaths among men. Targeted drug delivery is widely …

[HTML][HTML] Tumor-derived extracellular vesicles predict clinical outcomes in oligometastatic prostate cancer and suppress antitumor immunity

F Lucien, Y Kim, J Qian, JJ Orme, H Zhang… - International Journal of …, 2022 - Elsevier
Purpose SABR has demonstrated clinical benefit in oligometastatic prostate cancer.
However, the risk of developing new distant metastatic lesions remains high, and only a …

[HTML][HTML] D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

SS Gori, AG Thomas, A Pal, R Wiseman, DV Ferraris… - Pharmaceutics, 2022 - mdpi.com
Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in
numerous neurological disorders. The pharmacophoric requirements of active-site GCPII …

[68 Ga] Ga-PSMA-11 Small Bowel Uptake in Crohn's Disease: Revisiting the “Non-specificity” of PSMA Ligands

KR Chandekar, S Tanigassalam, AJ Kavanal… - Nuclear Medicine and …, 2022 - Springer
The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as
an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non …