Vaccines are one of the most significant medical interventions in the fight against infectious
diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the …

The emergence of artemisinin resistance is a major obstacle to the global malaria
eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is …

Abstract The World Malaria Report, released in December 2021, reflects the unique
challenges currently facing the global malaria community. The report showed the …

Background Controlled infection studies in malaria-naive adults suggest increased vaccine
efficacy for fractional-dose versus full-dose regimens of RTS, S/AS01. We report first results …

Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …

Malaria is estimated by the World Health Organization (WHO) to have killed 627,000
individuals worldwide in 2020, with nearly 80% of deaths in African children younger than …

Malaria parasites are less vulnerable to mosquito immune responses once ookinetes
transform into oocysts, facilitating parasite development in the mosquito. However, the …

Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-
terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major …

Abstract RTS, S/AS01 (Mosquirix®) is a vaccine against malaria caused by Plasmodium
falciparum. In a phase 3 trial, RTS, S/AS01 showed vaccine efficacy against clinical malaria …

The unique biology of Plasmodium vivax, with its ability to form latent hypnozoites in the liver
stage and the early appearance of gametocytes during blood stage infection, makes it …