Rapid, point‐of‐care antigen tests for diagnosis of SARS‐CoV‐2 infection

J Dinnes, P Sharma, S Berhane… - Cochrane database …, 2022 - cochranelibrary.com
Background Accurate rapid diagnostic tests for SARS‐CoV‐2 infection would be a useful
tool to help manage the COVID‐19 pandemic. Testing strategies that use rapid antigen tests …

Antibody tests for identification of current and past infection with SARS‐CoV‐2

T Fox, J Geppert, J Dinnes, K Scandrett… - Cochrane database …, 2022 - cochranelibrary.com
Background The diagnostic challenges associated with the COVID‐19 pandemic resulted in
rapid development of diagnostic test methods for detecting SARS‐CoV‐2 infection. Serology …

[HTML][HTML] Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a

S Lu, X Tong, Y Han, K Zhang, Y Zhang… - Nature biomedical …, 2022 - nature.com
CRISPR-based assays for the detection of nucleic acids are highly specific, yet they are not
fast, sensitive or easy to use. Here we report a one-step fluorescence assay for the detection …

[HTML][HTML] Comparative transmissibility of SARS-CoV-2 variants delta and alpha in New England, USA

R Earnest, R Uddin, N Matluk, N Renzette… - Cell Reports …, 2022 - cell.com
Summary The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by
an estimated 40%–80% increased transmissibility over Alpha. To investigate if this …

[HTML][HTML] Minimizing errors in RT-PCR detection and quantification of SARS-CoV-2 RNA for wastewater surveillance

W Ahmed, SL Simpson, PM Bertsch, K Bibby… - Science of the Total …, 2022 - Elsevier
Wastewater surveillance for pathogens using reverse transcription-polymerase chain
reaction (RT-PCR) is an effective and resource-efficient tool for gathering community-level …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Enhancing CRISPR-Cas-mediated detection of nucleic acid and non-nucleic acid targets using enzyme-labeled reporters

D Samanta, SB Ebrahimi, N Ramani… - Journal of the American …, 2022 - ACS Publications
We introduce a new method to generate an amplified signal in CRISPR-Cas-based
detection. Target recognition activates a CRISPR-Cas complex, leading to catalytic cleavage …

Effects of COVID-19 and mRNA vaccines on human fertility

F Chen, S Zhu, Z Dai, L Hao, C Luan, Q Guo… - Human …, 2022 - academic.oup.com
ABSTRACT The coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of …

[HTML][HTML] Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

A Unterman, TS Sumida, N Nouri, X Yan… - Nature …, 2022 - nature.com
Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe
COVID-19. However, the immune signatures associated with immunopathology are poorly …

[HTML][HTML] Developing RT-LAMP assays for rapid diagnosis of SARS-CoV-2 in saliva

X Huang, G Tang, N Ismail, X Wang - EBioMedicine, 2022 - thelancet.com
Background The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has killed
millions of people worldwide. The current crisis has created an unprecedented demand for …