The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

Human USP18 is an interferon (IFN)-stimulated gene product and a negative regulator of
type I IFN (IFN-I) signaling. It also removes covalently linked ISG15 from proteins, in a …

ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …

Interferons establish an antiviral state through the induction of hundreds of interferon-
stimulated genes (ISGs). The mechanisms and viral specificities for most ISGs remain …

Background Congenital ISG15 deficiency is a rare autoinflammatory disorder that is driven
by chronically elevated systemic interferon levels and predominantly affects central nervous …

One of the hallmarks of antiviral responses to infection is the production of interferons and
subsequently of interferon stimulated genes. Interferon stimulated gene 15 (ISG15) is among …

Type I interferons (IFN-Is) are a group of potent inflammatory and antiviral cytokines. They
induce IFN stimulated genes (ISGs), which act as proinflammatory mediators, antiviral …

ABSTRACT Interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like modifier that
binds to target proteins in a process termed ISGylation. ISG15, first described as an antiviral …