Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …

Condensed states of proteins, including liquid-like membraneless organelles and solid-like
aggregates, contribute in fundamental ways to the organisation and function of the cell …

Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production,
which is highly associated with normal physiological homeostasis and the pathogenesis of …

Cellular homeostasis requires the swift and specific removal of damaged material. Selective
autophagy represents a major pathway for the degradation of such cargo material. This is …

Autophagy is an evolutionarily conserved cellular process in which macromolecules
undergo lysosomal degradation. It fulfills essential roles in quality controlling cellular …

Abstract When p62/Sequestosome‐1 binds to a ubiquitinated protein, it undergoes liquid–
liquid phase separation (LLPS) and forms a membraneless organelle, p62 body. There are …

Age-related cell loss underpins many senescence-associated diseases. Apoptosis of lens
epithelial cells (LECs) is the important cellular basis of senile cataract resulted from …

Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as
ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the …

Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a
common characteristic of tauopathies. Although the neurodegenerative mechanism of tau …