Five priorities of African genomics research: the next frontier

A Wonkam, NS Munung, C Dandara… - Annual Review of …, 2022 - annualreviews.org
To embrace the prospects of accurately diagnosing thousands of monogenic conditions,
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …

Transferability of genetic risk scores in African populations

AB Kamiza, SM Toure, M Vujkovic, T Machipisa… - Nature Medicine, 2022 - nature.com
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data
in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived …

Human vulnerability and variability in the cold: Establishing individual risks for cold weather injuries

F Haman, SCS Souza, JW Castellani, MP Dupuis… - Temperature, 2022 - Taylor & Francis
Human tolerance to cold environments is extremely limited and responses between
individuals is highly variable. Such physiological and morphological predispositions place …

Enhancing the trajectories of cancer health disparities research: improving clinical applications of diversity, equity, inclusion, and accessibility

R Martini, E Gebregzabher, L Newman, MB Davis - Cancer Discovery, 2022 - AACR
In order to accurately detect and prevent racial disparities, self-reported race (SRR) and
ethnicity remain valuable tools; however, inaccurate capture of patient identity and broad …

The application of machine learning to predict genetic relatedness using human mtDNA hypervariable region I sequences

P Govender, SG Fashoto, L Maharaj, MA Adeleke… - Plos one, 2022 - journals.plos.org
Human identification of unknown samples following disaster and mass casualty events is
essential, especially to bring closure to family and friends of the deceased. Unfortunately …

Pharmacogenetics of breast cancer treatments: A Sub-Saharan Africa perspective

KC Nthontho, AK Ndlovu, K Sharma… - Pharmacogenomics …, 2022 - Taylor & Francis
Breast cancer is the most frequent cause of cancer death in low-and middle-income
countries, in particular among sub-Saharan African women, where response to available …

[PDF][PDF] Genetic and environmental variation impact transferability of polygenic risk scores

DS Araujo, HE Wheeler - Cell Reports Medicine, 2022 - cell.com
Even when polygenic risk scores (PRSs) are trained in African ancestral populations,
Kamiza and colleagues showed that genetic and environmental variation within sub …

[HTML][HTML] Genetic loci implicated in meta-analysis of body shape in Africans

M Nakabuye, AB Kamiza, O Soremekun… - Nutrition, Metabolism …, 2022 - Elsevier
Background and aims Obesity is one of the leading causes of non-communicable diseases
(NCD). Thus, NCD risk varies in obese individuals based on the location of their fat depots; …

Non-pharmacological interventions to achieve blood pressure control in African patients: a systematic review

M Cernota, ES Kroeber, T Demeke, T Frese… - BMJ open, 2022 - bmjopen.bmj.com
Objectives This systematic review aims to evaluate the evidence of non-pharmacological
strategies to improve blood pressure (BP) control in patients with hypertension from African …

Randomised controlled trials on prevention, diagnosis and treatment of diabetes in African countries: a systematic review

AS Sandholzer-Yilmaz, ES Kroeber, W Ayele… - BMJ open, 2022 - bmjopen.bmj.com
Objectives The epidemiological transition from infectious to chronic diseases leads to novel
challenges in African health systems. The prevalence of diabetes mellitus (DM) is increasing …