Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

When challenged with an invading pathogen, the host-defense response is engaged to
eliminate the pathogen (resistance) and to maintain health in the presence of the pathogen …

Calcimimetic agents allosterically increase the calcium ion sensitivity of the calcium-sensing
receptor (CaSR), which is expressed in the tubular system and to a lesser extent in …

Background Diabetic nephropathy (DN) is the major cause of kidney failure, and glomerular
podocytes play critical roles in the pathogenesis of DN by maintaining the glomerular …

Glomerular diseases are a major cause for chronic kidney disorders. In most cases podocyte
injury is causative for disease development. Cytoskeletal rearrangements and …

Background Steroid resistant nephrotic syndrome (SRNS) represents a significant renal
disease burden in childhood and adolescence. In contrast to steroid sensitive nephrotic …

Steroid-resistant nephrotic syndrome (SRNS) is a paradigmatic disease to illustrate the
major clinical consequences that can arise from genetic testing. Patients with pathogenic …

Rho family GTPases are molecular switches best known for their pivotal role in dynamic
regulation of the actin cytoskeleton, but also of cellular morphology, motility, adhesion and …

Background Focal and segmental glomerulosclerosis (FSGS) is a histological pathology that
characterizes a wide spectrum of diseases. Many genes associated with FSGS have been …