Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The postsynaptic density (PSD) is a massive protein complex, critical for synaptic strength
and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role …

In clinical settings, the information provided by genetic testing can explain the triggers and
processes underlying clinical presentations, such as neurodevelopmental disorders, in up to …

Biological functions of proteins rely on their specific interactions with binding partners. Many
proteins contain multiple domains, which can bind to their targets that often have more than …

Mutations in the well-known tumor suppressor PTEN are observed in many cancers. PTEN
is a dual-specificity phosphatase that harbors lipid and protein-phosphatase activities. The …

MAGI‐1 is a critical cellular scaffolding protein with over 110 different cellular and microbial
protein interactors. Since the discovery of MAGI‐1 in 1997, MAGI‐1 has been implicated in …

Oligomerization and complex formation play a key role for many membrane proteins and
has been described to influence ion channel function in both neurons and the heart. In this …

Excitatory (glutamatergic) synaptic transmission underlies many aspects of brain activity and
the genesis of normal human behavior. The postsynaptic scaffolding proteins SAP90/PSD …

Brain plasticity, in its simplest definition, is the ability of brain to change itself. This
phenomenon, which is important for the development and wiring of neuronal networks, is …

Allostery is the process of regulation of a protein caused by the binding of a ligand at a
distant region from the active site. It is one of the most widely studied properties of proteins …