[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
M Zoulikha, Q Xiao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …
several unmet medical needs, including acute lung injury/acute respiratory distress …
[HTML][HTML] Nanotechnology advances in the detection and treatment of cancer: an overview
Over the last few years, progress has been made across the nanomedicine landscape, in
particular, the invention of contemporary nanostructures for cancer diagnosis and …
particular, the invention of contemporary nanostructures for cancer diagnosis and …
[HTML][HTML] A perspective on oligonucleotide therapy: Approaches to patient customization
It is estimated that the human genome encodes 15% of proteins that are considered to be
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …
[HTML][HTML] Therapeutic siRNA: state-of-the-art and future perspectives
M Friedrich, A Aigner - BioDrugs, 2022 - Springer
The highly specific induction of RNA interference-mediated gene knockdown, based on the
direct application of small interfering RNAs (siRNAs), opens novel avenues towards …
direct application of small interfering RNAs (siRNAs), opens novel avenues towards …
Nebulization of extracellular vesicles: a promising small RNA delivery approach for lung diseases
Small extracellular vesicles (sEVs) are a group of cell-secreted nanovesicles with a diameter
up to 200 nm. A growing number of studies have indicated that sEVs can reflect the …
up to 200 nm. A growing number of studies have indicated that sEVs can reflect the …
Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model
LT Johnson, D Zhang, K Zhou, SM Lee… - Molecular …, 2022 - ACS Publications
Within the field of lipid nanoparticles (LNPs) for RNA delivery, the focus has been mainly
placed on organ level delivery, which can mask cellular level effects consequential to …
placed on organ level delivery, which can mask cellular level effects consequential to …
RNA cancer nanomedicine: nanotechnology-mediated RNA therapy
It has been demonstrated that RNA molecules—mRNA, siRNA, microRNA, and sgRNA—
regulate cancer-specific genes, and therefore, RNA-based therapeutics can suppress tumor …
regulate cancer-specific genes, and therefore, RNA-based therapeutics can suppress tumor …
Aptamer-conjugated nanoliposomes containing COL1A1 siRNA sensitize CRC cells to conventional chemotherapeutic drugs
H Manoochehri, A Jalali, H Tanzadehpanah… - Colloids and Surfaces B …, 2022 - Elsevier
COL1A1 is an important extracellular matrix component that is associated with poor
prognosis in cancers. In this study, As1411 aptamer-conjugated liposomes were used for …
prognosis in cancers. In this study, As1411 aptamer-conjugated liposomes were used for …
[HTML][HTML] Gene therapy to enhance angiogenesis in chronic wounds
Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …