The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Microglia are brain myeloid cells that play a critical role in neuroimmunity and the etiology of
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …

As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …

Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …

Translating human genetic findings (genome-wide association studies [GWAS]) to
pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Abstract Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid
(CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly …