Natural compounds for SIRT1‐mediated oxidative stress and neuroinflammation in stroke: a potential therapeutic target in the future

C Fang, H Xu, L Yuan, Z Zhu, X Wang… - Oxidative medicine …, 2022 - Wiley Online Library
Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial
economic and social costs. ROS production and neuroinflammation have been implicated in …

Soluble epoxide hydrolase as a therapeutic target for neuropsychiatric disorders

J Shan, K Hashimoto - International journal of molecular sciences, 2022 - mdpi.com
It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the
metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which …

Selected mediators of inflammation in patients with acute ischemic stroke

H Pawluk, R Kołodziejska, G Grześk… - International Journal of …, 2022 - mdpi.com
During a stroke, a series of biochemical and metabolic changes occur which eventually lead
to the death of cells by necrosis or apoptosis. This is a multi-stage process involving …

The construction and analysis of immune infiltration and competing endogenous RNA network in acute ischemic stroke

ZL Ma, CF Liu, L Zhang, N Xiang, Y Zhang… - Frontiers in aging …, 2022 - frontiersin.org
Acute ischemic stroke (AIS) is a common neurological disease that seriously endangers
both the physical and mental health of human. After AIS, activated immune cells are …

Impact of age on systemic inflammatory profile of patients with ST-segment–elevation myocardial infarction and acute ischemic stroke

T Bochaton, S Leboube, A Paccalet, C Crola Da Silva… - Stroke, 2022 - Am Heart Assoc
Background: Aging is associated with a chronic low-grade inflammatory state. This condition
may affect the acute inflammatory response involved in ST-segment–elevation myocardial …

Platelet endothelial cell adhesion molecule (PECAM/CD31) blockade modulates neutrophil recruitment patterns and reduces infarct size in experimental ischemic …

NA Nadkarni, E Arias, R Fang, ME Haynes… - The American Journal of …, 2022 - Elsevier
The infiltration of polymorphonuclear leukocytes (PMNs) in ischemia-reperfusion injury (I/RI)
has been implicated as a critical component of inflammatory damage following ischemic …

The role of concomitant Nrf2 targeting and stem cell therapy in cerebrovascular disease

J Gordon, G Lockard, M Monsour, A Alayli… - Antioxidants, 2022 - mdpi.com
Despite the reality that a death from cerebrovascular accident occurs every 3.5 min in the
United States, there are few therapeutic options which are typically limited to a narrow …

[HTML][HTML] Serum total cholesterol level as a potential predictive biomarker for neurological outcomes in cardiac arrest survivors who underwent target temperature …

C Ahn, C Kang, HJ Ahn, Y You, JS Park, JH Min… - Medicine, 2022 - journals.lww.com
Cholesterol is an essential substance to maintain cell membranes. Low levels of total
cholesterol (TC) are associated with poor prognosis in critically ill patients. Cardiac arrest …

Predictors for symptomatic intracranial hemorrhage after intravenous thrombolysis with acute ischemic stroke within 6 h in northern China: a multicenter, retrospective …

Y Xue, S Li, Y Xiang, Z Wang, F Wang, Y Yu, P Yan… - BMC neurology, 2022 - Springer
Background and purpose This study assessed the predictive factors for symptomatic
intracranial hemorrhage (sICH) in patients with acute ischemic stroke (AIS) after receiving …

The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective

H Chen, F Liu, D Sun, J Zhang, S Luo, Q Liao… - Frontiers in …, 2022 - frontiersin.org
Background Mounting evidence strongly uncovered that peripheral immuno-inflammatory
response induced by acute stroke is associated with the appearance of post-stroke …