Microbiota and maintenance of skin barrier function

TA Harris-Tryon, EA Grice - Science, 2022 - science.org
Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

[HTML][HTML] The human microbiota and skin cancer

YR Woo, SH Cho, JD Lee, HS Kim - International Journal of Molecular …, 2022 - mdpi.com
Skin cancer is the most common type of cancer in the US with an increasing prevalence
worldwide. While ultraviolet (UV) radiation is a well-known risk factor, there is emerging …

Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis

Z Fang, T Pan, L Li, H Wang, J Zhu, H Zhang… - Gut …, 2022 - Taylor & Francis
Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD)
via the aberrant immune response. Some Bifidobacterial species and strains have been …

[HTML][HTML] Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite

G Renga, E Nunzi, M Pariano, M Puccetti… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Despite the great success, the therapeutic benefits of immune checkpoint
inhibitors (ICIs) in cancer immunotherapy are limited by either various resistance …

A dysregulated sebum–microbial metabolite–IL-33 axis initiates skin inflammation in atopic dermatitis

Z Qiu, Z Zhu, X Liu, B Chen, H Yin, C Gu… - Journal of Experimental …, 2022 - rupress.org
Microbial dysbiosis in the skin has been implicated in the pathogenesis of atopic dermatitis
(AD); however, whether and how changes in the skin microbiome initiate skin inflammation …

[HTML][HTML] Manipulating microbiota to treat atopic dermatitis: functions and therapies

MJ Alam, L Xie, YA Yap, FZ Marques, R Robert - Pathogens, 2022 - mdpi.com
Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on
children. Current therapies for AD are challenged by the limited armamentarium and the …

Local and systemic effects of microbiome‐derived metabolites

I Spivak, L Fluhr, E Elinav - EMBO reports, 2022 - embopress.org
Commensal microbes form distinct ecosystems within their mammalian hosts, collectively
termed microbiomes. These indigenous microbial communities broadly expand the genomic …

[HTML][HTML] Keratinocytes: an enigmatic factor in atopic dermatitis

P Das, P Mounika, ML Yellurkar, VS Prasanna… - Cells, 2022 - mdpi.com
Atopic dermatitis (AD), characterized by rashes, itching, and pruritus, is a chronic
inflammatory condition of the skin with a marked infiltration of inflammatory cells into the …

Dietary tryptophan-mediated aryl hydrocarbon receptor activation by the gut microbiota alleviates Escherichia coli-induced endometritis in mice

C Zhao, L Bao, M Qiu, L Feng, L Chen, Z Liu… - Microbiology …, 2022 - Am Soc Microbiol
Intestinal microbiota-mediated aryl hydrocarbon receptor (AhR) activation plays an important
role in host–microbiota interactions and disease development. However, whether AhR …

Indole-3-propionic acid alleviates ischemic brain injury in a mouse middle cerebral artery occlusion model

Y Xie, X Zou, J Han, Z Zhang, Z Feng, Q Ouyang… - Experimental …, 2022 - Elsevier
Increasing evidence highlights the importance of gut microbiota and its metabolites as an
environmental factor affecting ischemic stroke. However, the role of microbial indole …